The US has said the rule of Syrian President Bashar al-Assad is coming to an end, as Western and Arab nations push for a UN Security Council resolution.
Washington is seeking to convince Russia not to stand in the way of the Arab League's initiative, to be presented to the Security Council in New York on Tuesday, calling for Assad to transfer power to help resolve the crisis.
"Assad's fall is inevitable," Jim Carney, the White House spokesman, said on Monday.
"As governments make decisions about where they stand on this issue and what steps need to be taken with regards to brutality of Assad's regime, it's important to calculate into your consideration the fact that he will go. The regime has lost control of the country and he will eventually fall."
Damascus dismissed Western criticism and said it would defeat what it called foreign attempts to spread chaos.
"We are not surprised at the lack of wisdom or rationality of these statements and regret that they are still issued by
countries that are used to making the Middle East an arena for their follies and failures," the state news agency quoted a foreign ministry source as saying.
"Syria, which is defending itself today against terrorism and will continue to do so, will be the exception which ... will
foil the policies of chaos adopted by these countries," it said.
Violence escalating
The comments came as fighting seemed to escalate on the ground in Syria, where activists said about 100 people were killed on Monday.
Troops battled anti-Assad fighters in the central city of Homs and in suburbs of the capital, Damascus.
The Local Co-ordination Committees said the majority of the victims died in Homs province, many of them in the town of Rastan, where the army shelled residential buildings.
Al Jazeera
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